Saturday, March 8, 2008

Approximately 50% of affected families have a negative family history;in many of these families, the father is older,


suggesting that advanced paternal age may influence the NF-1 mutation.NF-2 is an autosomal dominant disorder of chromosome 22; however,many patients have a negative family history



Neurofibromatisis
Neurofibromatosis is a group of inherited development disorders of the nervous system,muscles,bones,and skin that causes formation of multiple,pedunculated,soft tumors, and cafe-au-lait spots. The most common types are NF-1 (von Recklinghausen disease) and NF-2 (bilateral acoustic neurofibromatosis). About 80,000 Americans are known to have neurofibromatosis; in many others, the disorder is overlooked because symptoms are mild. the prognosis varies; however, spinal or intracranial tumors can shorten the patient's life span.Causes and IncidenceNF-1 is an autosomal dominant disorder of chromosome 17 that occurs in about 1 in 30,000 births. Approximately 50% of affected families have a negative family history;in many of these families, the father is older,suggesting that advanced paternal age may influence the NF-1 mutation.NF-2 is an autosomal dominant disorder of chromosome 22; however,many patients have a negative family history.

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March 18, 2008 at 1:12 AM  
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March 18, 2008 at 1:12 AM  

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