4/ 5 LESCH-NYHANS IN WHICH THE MOTHER WAS NEW MUTATION, AGE OF HER PARENTS WAS CONSIDERABLY HIGHER THAN THE MEAN PARENTAL AGE IN THE POPULATION.

THIS RAISES THE POSSIBILITY OF PATERNAL AGE EFFECT X-LINKED MUTATIONS


The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.
U Francke, J Felsenstein, S M Gartler, B R Migeon, J Dancis, J E Seegmiller, F Bakay, and W L Nyhan
This article has been corrected. See Am J Hum Genet. 1976 May; 28(3): 311.
This article has been cited by other articles in PMC.
AbstractIn a population at equilibrium for a sex-linked lethal, one-third of the genes for that lethal must arise anew each generation. Therefore, one-third of all cases of Lesch-Nyhan disease, a severe X-linked recessive lethal disorder, should be new mutants. To test this hypothesis, we have collected 47 families, 20 with a single proband and 27 with multiple affected males in which the patients' mothers and other female relatives had been studied for heterozygosity. Available carrier detection tests identify heterozygous for HPRT deficiency in hair roots and skin fibroblasts. Only four mothers were found not to be carriers. This result deviates significantly from expected (P less than .001). Statistical tests for ascertainment effects indicated absence of bias for multiple proband families but strong bias in favor of families with many heterozygous females. When the analysis was limited to single proband families, the deviation from expected was still significant (P less than .01). The incidence of new mutants among the heterozygous mothers, as determined by the ratio of +/+ to +/- maternal grandmothers, should be one-half (see Appendix). Of all 20 maternal grandmothers studied, five were +/+ and 15 were +/- (P less than .05). Considering only the single proband families, the ratio of 5 +/+ to 8 +/- was not significantly different from expected. In four of the five cases in which the heterozygous mother of an affected individual was a new mutation, the age of her parents was considerably higher than the mean parental age in the population. This raises the possibility of a paternal age effect on X-linked mutations. There appears to be a true deficiency of new mutatnts among males but not among females. Data on additional Lesch-Nyhan families are needed before conclusions regarding a possible higher mutation rate in males can be drawn.Full textFull text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.6M), or see the PubMed citation or the full text of some References or click on a page below to browse page by page.

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