SOMATIC OR GERMLINE MOSAICISMS WERE EXCLUDED IN MANY MOTHERS SUGGESTING SUCH MOSAICISMS ARE A RARE EVENT IN FAMILIES WITH INVERSION OF INTRON 22

THE INVERSIONS ORIGINATED ALMOST EXCLUSIVELY IN THE MALE GERM LINE

Haemophilia. 2003 Sep;9(5):584-7. Links
Exclusion of mosaicism in Spanish haemophilia A families with inversion of intron 22.Tizzano EF, Cornet M, Domenech M, Baiget M.
Department of Genetics, Hospital of Sant Pau, Barcelona, Spain. etizzano@hsp.santpau.es

Inversion of intron 22, the most frequent mutation event in haemophilia A (HA), was tested in our HA families to diagnose the females at risk of being carriers, to trace the origin of the mutation and to investigate the presence of germinal or somatic mosaicism. A total of 166 females belonging to 54 families with inversion, were analysed. All but one of the mothers tested were carriers and the inversion originated almost exclusively in male germ cells. Somatic or germline mosaicisms were excluded in 53 of these women and in 20 grandfathers, suggesting that such mosaicisms may be a rare event in families with inversion of intron 22.